Otsuka K, Otsuka H, Matsune S, Okubo K.: Decreased numbers of methachromatic cells in nasal swab in Japanese cedar pollinosis following sublingual immunotherapy. Immun Inflamm Dis. 2020 May 28. doi: 10.1002/iid3.314. Online ahead of print.PMID: 32468704
Okubo K, Okano M, Sato N, Tamaki Y, Suzuki H, Uddin A, Fogel R.: Add-on omalizumab for inadequetly controlled severe pollinosis despite standard-of-care: A randomized study. J Allergy Clin Immunol Pract. 2020 May 11:S2213-2198(20)30471-2. doi: 10.1016/j.jaip.2020.04.068. Online ahead of print.
Calderon MA, Waserman S, Bernstein DI, Demoly P, Douglass J, Gagnon R, Katelaris CH, Kim H, Nelson HS, Okamoto Y, Okubo K, Virchow JC, DuBuske L, Casale TB, Canonica GW, Nolte H.Clinical Practice of Allergen Immunotherapy for Allergic Rhinoconjunctivitis and Asthma: An Expert Panel Report. J Allergy Clin Immunol Pract. 2020 May 16:S2213-2198(20)30479-7. doi: 10.1016/j.jaip.2020.04.071. Online ahead of print.
Otsuka K, Otsuka H, Matsune S, Okubo K.Allergen-specific subcutaneous immunotherapy for Japanese cedar pollinosis decreases the number of metachromatic cells and eosinophils in nasal swabs during the preseason and in season. Immun Inflamm Dis. 2020 Apr 2. doi: 10.1002/iid3.301. Online ahead of print.PMID: 32239697
Nomura Y, Okubo K, Nakamura T, Sawaki S, Kitagou H, Idei N, Kaneko S, Kobayashi S, Tanaka Y, Okamoto Y.: Long-term treatment of Japanese cedar pollinosis with Japanese cedar pollen SLIT drops and persistence of treatment effect; A post-marketing clinical trial. Allergology Int. 2020 Jul 8:S1323-8930(20)30072-1. doi: 10.1016/j.alit.2020.05.008. Online ahead of print. PMID: 32653209
Yonekura S, Okamoto Y, Sakurai D, Okubo K, Gotoh M, Kaneko S, Konnno A: An analysis of factors related to the effect of sublingual immunotherapy on Japanese cedar pollen induced allergic rhinitis. See comment in PubMed Commons belowAllergol Int.2017 Jul 28. pii: S1323-8930(17)30106-5. doi: 10.1016/j.alit.2017.07.005. [Epub ahead of print]
Gotoh M, Kaminuma O, Nakaya A, Katayama K, Motoi Y, Watanabe N, Saeki M, Nishimura T, Kitamura N, Yamaoka K, Okubo K, Hiroi T: Identification of biomarker sets for predicting the efficacy of sublingual immunotherapy against pollen-induced allergic rhinitis. Int Immunol.2017 Jun 1;29(6):291-300. doi: 10.1093/intimm/dxx034.
Okubo K, Masuyama K, Imai T, Okamiya K, Seitzberg D, Konno A： Efficacy and Safety of the SQ house dust mite SLIT-tablet in Japanese adults and adolescents with dust mite-induced allergic rhinitis J AllergyClin Immunol. 2017 Jun;139(6):1840-1848.e10. doi: 10.1016/j.jaci.2016.09.043. Epub 2016 Nov 15
Kanzaki S, Hashiguchi K, Wakabayashi KI, Suematsu K, Okubo K: Histamine antagonist bepotastine suppress nasal symptom cussed by Japanese cedar and cypress pollen exposure. J Drug Asess 2016 Sep 27; 5(1): 15-23.
Otsuka H, Tsukagoshi H, Kimura H, Takahashi I, Okubo K: Are respiratory viruses involved in preseasonal symptoms or severity in Japanese cedar pollinosis? Allergy Rhinol (Providence) 2016 Jan; 7(2): 62-8. Doi; 10.2500/ar.2016.7.0157.
Bousquet J, Farrell J, Crooks G, Okubo K, et al (256): Scaling up strategy of the chronic respiratory disease programme of the European innovation partnership on active and healthy aging (Actin plan B3: Area 5) Clin Transl Allergy 2016 Jul 29;6:29 doi: 10.1186/s13601-016-0116-9. Review.
Miwa M, Hassan S, Miwa M, Okubo K: Filaggrin exists in human nose. Allergol Int 2016 Jul; 65(3): 338-40. Doi: 10.1016/j.alit.2016.01.007.
Okubo K, Gotoh M, Togawa M, Saito A, Ohhashi Y (2016) Long-term safety and efficacy of bilastine following up to 12 weeks to 52 weeks of treatment of Japanese patinents with allergic rhinitis: Resluts of an open-label trial. Auris Nasus Larynx http://dx.doi.org/10.1016/j.anl.2016.07.021
Okubo K, Inoue H, Numaguchi H, Tanaka K, Saito I, OshimaN, Matsumoto Y, Prohn M, Mehta A, Nishida C, Philip G (2016) Montelukast in the treatment of perennial allergic rhinitis in pediatric Japanese patients; an open-label clinical trial, J Drug Assess http://dx.doi.org/10.1080/21556660.2016.1209507
Okubo K, Gotoh M, Asako M, Nomura Y, Togawa M, Saito A, Honda T, Ohnashi Y (2016) Efficacy and safety of birastine in Japanese patients with perennial allergic rhinitis: A muti-center, randomized, double-blind, placebo-controlled, parallel-group phase III study. Allergology Int the CC BY-NC-ND license http://creativecommons.org/licenses/by-nc-nd/4.0/.
Mochizuki M, Minowa F, Ishimoto C, Gin A, Ishioka K, Okubo K (2016) The effect of aging biochemical markers in equine serum. J Equine Veterinary Sci 42:1-6. Doi.org/10.1016/j.jevs.2016.03.011
Hashiguchi K, Wakabayashi K, Togawa M, Saito A, Okubo, K (2016) Therapeutic effect of bilastine in Japanese cedar pollinosis using an artificial exposure chamber (OHIO chamber). Allergology Int doi.org 10.1016/j.alit.2016.06.009
Otsuka H, Takanashi I, Tokunou S, Endo S, Okubo K (2016) Involvemnet of Stahylococcus aureus and Moraxella catarrhalis in Japanese cedar pollionosis. Am J Rhinol Allergy 30: 99-106, doi:10.2500/ajra.2016.30.4283
Yonekura S, Okamoto Y, Sakurai D, Sakurai T, Iinuma T, Yamamoto H, Hanazawa T, Horiguchi S, Kurono Y, Honda K, Majima Y, Masuyama K, Takeda N, Fujieda S, Okano M, Ogino S, Okubo K: Complementary and alternative medicine for allergic rhinitis in Japan.Allergol Int. 2017 Jul;66(3):425-431. doi: 10.1016/j.alit.2016.10.006. Epub 2016 Nov 21.
Okubo K, Ichimura I, Koyama T, Susuta Y, Izaki H (2015) Double-blind placebo-controlled study of bepotastine besilate in pediatric patients with perennial allergic rhinitis. Expert Opin Pharmacother2015; 16(16): 2395-408. Doi: 10.1517/14656566.2015. 1085511.
Bousquet J, Schunemann HJ, Fonseca J, Okubo K, et al(283): MACVIA-ARIA sentinel network for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation. Allergy 2015 Nov; 70(11): 1372-92. Doi 10.111/all.12686. Review
Okamoto Y, Okubo K, Yonekura S, Hashiguchi K, Goto M, Otsuka T, Murata T, Nakao Y, Kanazawa C, Nagakura H, Okawa T, Nakano K, Hisamitsu M, Kaneko S, Konno A(2015) Efficacy and safety of sublingual immunotherapy for two seasons in patients with Japanese cedar pollinosis. Int Arch Allergy Immunol 166(4): 177-188
Takai T, Okamoto Y, Okubo K, Nagata M, Sakaguch M, Fukutomi Y, Saito A, Yasuueda H, Masuyama K: Japanese Society of Allergology task force report on standardization of house dust mite allergen vaccines-secondary publication. Allergol Int 2015 apr 64(2): 1816 doi 10.1016/j.alit2015.01.005.
Okubo K, Okamasa A, Honma G, Komatubara M(2015) Safety and efficacy of fuluticosone furorate nasal spray in Japanese children 2 to <15 years of age with perennial allergic rhinitis: A mutisentre, open-label trial. Allergol Int 64(1)Jan: 60-65.
Okubo K, Okamasa A, Honma G, Komatubara M(2014) Efficacy and safety of fuluticosone furorate nasal spray in Japanese children with perennial allergic rhinitis: a mutisentre, randomized, double-blind, placebo-contorolled trial. Allergol Int 63(4)Dec: 543-551.
Hosoya K, Masuno S, Hashiguchi K, Okubo K (2014) Placebo-controlled study with OHIO chamber of prophylactic puranlukast for children with Japanese cedar pollinosis: TOPIC-J III study. J Drug Assessment 3: 51-59.
Hashiguchi K, Kanzaki S, Wakabayashi K, Tanaka N, Kawashima K, Suematsu K, Tokunaga S, Ogawa K, Okubo K(2013) Efficacy of fuluticasone furoate nasal spray and levocetirizine in patients with Jpanese cadar pollinosis subjected to an artificial exposure chamber. J Drug Assessment 2: 94-105.
Sashihara T, Nagata M, Mori T, Gotoh M, Okubo K, Uchida M, Itoh H(2013) Effect of Lactobacillus gasseri OLL2809 and alfa-lactalbumin on university-student athletes: a randomized, double blind, placebo-controlled clinical trial. Appl Physiol Nutr Metab 38: 1228-1235.
Higaki T, Okano M, Kariya S, Fujiwara T, Haruna T, Hirai H, Murai A, Gothoh M, Okubo K, Yonekura S, Okamoto Y, Nishizaki K(2013) Determining Minimal Clinically Important Differences in Japanese Cedar/Cypress Pollinosis Patients. Allergology Int 62(4):487-93.
Gotoh M, Yuta A, Ohta N, Matsubara A, Okubo K (2013) Severity Assessment of Japanese Cedar Pollinosis Using the Practical Guideline for the Management of Allergic Rhinitis in Japan and the Allergic Rhinitis and its Impact on Asthma Guideline. Allergology Int 62(2): 181-189.
Gotoh M, Okubo K, Hashiguchi K, Wakabayashi K, Kanzaki S, Tanaka N, Fujioka M, Kawashima K, Suematsu K, Sasaki K, Iwasaki M, Yamamotoya H(2013) Noninvasive biological evaluation of response to pranlukast treatment in pediatric patients with Japanese cedar pollinosis. Allergy Asthma Proc. 33(6): 459-466.
Ohashi R, Wakayama N, kawamoto M, Tsuchiya S, Okubo K (2013) Solitary nasal schwannoma: Usefulness of CD34 and calretinin staining for distinction from histological mimics. J Nippon Med Sch 80(4): 300-306.
Fujikura T, Ishida M, Sekine K, Aoki H, Okubo K (2012) Solitary Fibrous Tumor Arising from the Superior Nasal Turbinate: A Case Report. J Nippon Med Sch 79(5): 373-376.
Ishida A, Ohta K, Suzuki Y, Kakehata S, Okubo K, Ikeda H, Shiraishi H, Izuhara K (2012) Expression of pendrin and periostin in allergic rhinitis and chronic rhinosinusitis. Allergology Int 61 (4Dec): 589-595.
Kamio T, Watanabe K, Okubo K (2012) Acoustic stimulation promotes DNA fragmentation in the guinea pig cochlea. J Nippon Med Sch 79(5): 349-356.
Bousquet J, Schnemann HJ, Samolinski B, et al 162/226 in collaboration with the World Health Organization Collaborating center for Asthma and Rhinitis(2012) Allergic rhinitis and its impact on asthma (ARIA): Achievements in 10 years and future needs. J Allergy Clin Immunol 130(5): 1049-1062.
Hashiguchi K, Okubo K, Wakabayashi K, Tanaka N, Watada Y, Suematsu K, Gotoh M (2012) The assessment of the optimal duration of early intervention with montelukast in the treatment of Japanese cedar pollinosis symptom induced in an artificial exposure chamber. J Drug Assessment 1: 40-47.
Endo S, Gotoh M, Okubo K, Hashiguchi K, Suzuki H, Masuyama K (2012) Trial of pranlukast inhibitory effect for cedar exposure using an OHIO chamber. J Drug Assessment 1: 48-54.
Mori S, Pawankar R, Ozu C, Nonaka M, Yagi T, Okubo K (2012) Expression and role of MMP-2, MMp-9, MMP-13, TIMP-1 and TIMP-2 in allergic nasal mucosa. Allergy Asthma Immunol Res 4(4):231-239.
Shiiba K, Shindo S, Ikesono T, Sekine K, Matsumura T, Sekiguchi S, Yagi T, Okubo K (2012) Cochlin expression in the rat perilymph during postnatal development. Acta Oto-Laryngologica 132(11):1134-9.
Igarashi T, Nakazato Y, Kunishige T, Fujita M, Yamada Y, Fujimoto C, Okubo K, Takanhashi H (2012) Mometasone furorate nasal spray releaves the ocular symptoms of seasonal allergic rhinoconjunctivitis. J Nippon Med Sch 79(3): 182-189.
Inai S, Watanabe K, Okubo K (2012)Iducible nitric oxide synthase in cochlear damage after acoustic stimulation in Guinea pigs. J Nippon Med Sch 79(2): 121-128.
Wakabayashi K, Hashiguchi K, Kanzaki S, Fujioka M, Tanaka N, Kawashima K, Suematsu K, Yamamotoya H, Iwasaki M, Gotoh M, Horibe S, Naito K, Okubo K (2012) Puranlukast dry syrup inhibits symptoms of Japanese cedar pollinosis in children using OHIO chamber. Allergy Asthma Proc 33(1): 102-109.
Yokoshima K, Nakamizo M, Sakanushi A, Ozu R, Yamaguchi S, Tone Y, Inai S, Murakami R, Okubo K (2011) Surgical management of tongue cancer during pregnancy. Auris Nasus Larynx 39(4): 428-430.
Kimura S, Pawankar R, Mori S, Nonaka M, Masuno S, Yagi T, Okubo K (2011) Increased expression and role of thymus stromal lymphopoietin in nasal polyposis. Allergy Asthma Immunol Res 3(3): 186-193.
Gotoh M, Suzuki H, Okubo K (2011) Delay of onset of symptoms of Japanese cedar pollinosis by treatment with a leukotriene receptor antagonist. Allergol Int 60: 483-489.
Ikesono T, Shindo S, sekine K, Shiiba K, Matsuda H, Kusama K, Koizumi Y, Sugizaki K, Sekiguchi S, Kataoka R, Pawankar R, Baba S, Yagi T, Okubo K (2011) Cochlin-tomoprotein (CTP) detection test identifies traumatic perilynphatic fistula due to penetrating middle ear injury. Acta Otolaryngol 131(9): 937-944.
Yonekura S, Okamoto Y, Yamasaki K, Horiguchi S, Hanazawa T, Matsune S, Kurono Y, Yamada T, Fujieda S, Okano M, Okubo K (2011) A randomized double-blind, placebo-controlled study of Ten-Cha (Rubus suavissimus) on house dust mite allergic rhinitis. Auris Nasus Larynx 38: 600-607.
Fujikura T, Okubo K (2011) Adrenomedulin level in the nasal discharge from allergic rhinitis cohort. Peptide 32: 368-373.
Yamanaka K, Yuta A, Kakeda M, Kitagawa H, Ogihara H, Gabazza EC, Okubo K, Kurokawa I, Takeuchi K, Mizutani K (2011) SLIT improves cedar pollinosis by restoring IL-10 production form Tr1 and monocyte -IL-10 productivity is critical for becoming allergic- Allergol Int 60: 45-51.
Gotoh M, Hashiguchi K, Okubo K (2011) Efficacy of epinastine hydrochloride for antigen-provoked nasal symptoms in subjects with orchard grass pollinosis. Allergol Int 60(1): 69-77.
Nishihata S, Murata T, Inose K, Okubo K, Sahashi N, Takahashi H, Hirooka J, Hoshiyama Y, Murayama K, Mezawa A, Yokoyama T, Endo T, Saiga T, Saito Y (2010) Prevalence of Japanese cedar pollinosis in Tokyo: a survey conducted by the Tokyo Metropolitan Government. Clin Exp Allergy Rev 10(8): 8-11.
Okubo K, Okuda M, Magara H, Kaneko K (2010) Olopatadine hydrochloride in children: efficacy and safety for perennial allergic rhinitis. Curr Med Res Opin 26(7): 1657-1665.
Makino Y, Noguchi E, Takahashi N, Mastumoto Y, Kubo S, Yamada T, Imoto Y, Ito Y, Osawa Y, Shibasaki M, Uchida K, Meno K, Suzuki H, Okubo K, Arinami T, Fujieda S (2010) Apolipoprotein A-IV is a candidate target molecule for the treatment of seasonal allergic rhinitis. J Allergy Clin Immunol 126(6): 1163-1169, e5.
Gotoh M, Okubo K, Okuda M, Hamada C (2010) Clinical pharmacology study of the corticosteroid nasal spray dexamethasone cipecilate (NS-126): examination of the efficacy in the nasal induction test. Expert Opin Investig Drugs. 19: 1475-1486.
Okubo K, Uchida E, Nogami S (2010) Levocabastine nasal spray significantly improves perennial allergic rhinitis: A single blind placebo-controlled study. Auris Nasus Larynx 37: 436-442.
Okubo K, Nakashima M, Miyake N, Komatsubara M, Okuda M. (2009) Comparison of fluticasone furoate and fluticasone propionate for the treatment of Japanese cedar pollinosis. Allergy Asthma Proc. 30:84-94.
OginoS, Nagakura T, Okubo K, Sato N, Takahashi M, Ishikawa T. (2009) Re-treatment with omalizumab at one year interval for Japanese cedar pollen-induced seasonal allergic rhinitis is effective and well tolerated.Int Arch Allergy Immunol 149:239-245.
Sasaki K, Okamoto Y, Yonekura S, Okawa T, Horiguchi S, Chazono H, Hisamitsu, Sakurai D, Hanazawa T, Okubo K. (2009) Cedar and cypress pollinosis and allergic rhinitis: Quality of life effects of early intervention with leukotriene receptor antagonists. Int Arch Allergy Immunol 149: 350-358.
Hashiguchi K, TangH, FujitaT, SuematsuK, TsubakiS, NagakuraH, Kitajima S, GotohM, OkuboK (2009) Validation study of the OHIO chamber in patients with Japanese Cedar pollinosis. Int Arch Allergy Immunol 149:141-149.
Hashiguchi K, Tang H, Fujita T, Suematsu K, Gotoh M, Okubo K. (2009) Bepotastine besilate OD tablets suppress nasal symptoms caused by Japanese cedar pollen exposure in an artificial exposure chamber (OHIO Chamber).Expert Opin Pharmacother 10: 523-9.
Gotoh M, Sashihara T, Ikegami S, Yamaji T, Kino K, Orii N, Taketomo N, Okubo K. (2009) Efficacy of Oral Administration of a Heat-Killed Lactobacillus gasseri OLL2809 on Patients of Japanese Cedar Pollinosis with High Japanese-Cedar Pollen-Specific IgE. Biosci Biotechnol Biochem 73: 90144-1-7.
Okubo K, Baba K (2008) Therapeutic effect of montelukast, a cysteinyl leukotriene receptor 1 antagonist, on Japanese patients with seasonal allergic rhinitis. Allergol Int 57: 247-255.
Okubo K, Gotoh M, Fujieda S, Okano M, Yoshida H, Morikawa H, Masuyama K, Okamoto Y, Kobayashi M (2008) A randomized double-blind comparative study of sublingual immunotherapy for cedar pollinosis. Allergol Int 57: 265-275.
Okubo K, Nakashima M, Miyake N, Komatsubara M, Okuda M. (2008) Dose-ranging study of fluticasone furoate nasal spray for Japanese patients with perennial allergic rhinitis. Curr Med Res Opin 24: 3393-3403.
Sakashita M, Yasuda1 K, Hirota T, Harada M, Ohkubo K, Osawa Y, Fujieda S, Nakamura S, Nakanishi K, YoshimotoT, Tamari M. (2008) Association of serum IL-33 level and the IL-33 genetic variant withJapanese cedar pollinosis. Clin Exp Allergy 38: 181875-1881.
Okano M, Otsuki N, Azuma M, Fujiwara T, Kariya S, Sugata Y, Higaki T, Kino K, Tanimoto Y, Okubo K, Nishizaki K (2008) Allergen-specific immunotherapy alters the expression of BTLA, a co-inhibitory molecule, in allergic rhinitis. Clin Exp Allergy 38: 1891-1900.
Sashihara T, Ikegami S, Sueki N, Yamaji T, Kino K, Takemoto N, Gotoh M, Okubo K (2008) Oral administration of heat-killed Lactobacillus gasseri OLL2809 reduces cedar pollen antigen-induced peritoneal eosinophilia in mice. Allergol Int 57: 397-403.
Okubo K, Baba K (2008) A double-blind non-inferiority clinical study of montelukast, acysteinyl leukotriene receptor antagonist, compared with Pranlukast in patients with seasonal allergic rhinitis. Allergol Int 57: 383-390.
Hashiguchi K, Tang H, Fujita T, Tsubaki S, Fujita M, Suematsu K, Gotoh M, Okubo K. (2007) Preliminary study on Japanese cedar pollinosis in an artificial exposure chamber (OHIO chamber). Allergol Int 56: 125-130.
Nagakura T, Ogino S, Okubo K, Sato N, Takahashi M, Ishikawa T. (2007) Omalizumab is more effective than suplatast tosilate in the treatment of Japanese cedar pollen-induced seasonal allergic rhinitis. Clin Exp Allergy 38: 329-337.
Okubo K, Gotoh M. (2006) Inhibition of the antigen provoked nasal reaction by second-generation antihistamines in patients with Japanese cedar pollinosis. Allergology International 55: 261-269.
Okubo K, Ogino S, Nagakura T, Ishikawa T. (2006) Omalizumab is effective and safe in the treatment of Japanese cedar pollen-induced seasonal allergic rhinitis. Allergol Int 55: 379-386.
Okubo K, Gotoh M, Shimada K, Ristu M, Okuda M, Crawford B. (2005) Fexofenadine improves the quality of life and work productivity in Japanese patients with seasonal allergic rhinitis during the peak cedar pollinosis season. Int Arch Allergy Immunol 136: 148-154.
Gotoh M, Okubo K. (2005) Sublingual immunotherapy for Japanese cedar pollinosis. Allergol Int 54: 167-171.
Okuda M, Ohkubo K, Goto M, Okamoto Y, Konno A, Baba K, Ogino S, Enomoto M, Imai T, So N, Ishikawa Y, Takenaka Y, Manndai T, Crawford B. (2005) Comparative study of two Japanese rhinoconjunctivitis quality-of-life questionnaires. Acta Oto-Laryngologica 125: 10. 736-744.
Gotoh M, Okubo K, Okuda M. (2005) Inhibitory effects of facemasks and eyeglasses on invasion of pollen particles in the nose and eye: clinical study. Rhinology 43: 266-270.
Okubo k, Gotoh, Okuda M. (2004) Prevalence of Japanese cedar pollinosis in children aged under 15 years throughout Japan. Clin Exp Allergy Rev 4:31-34, 2004.
Okubo K, Gotoh M, Shimada K, Ritsu M, Kobayashi M, Okuda M. (2004) Effect of fexofenadine on the quality of life of Japanese cedar pollinosis patients. Allergol Int 53: 245-254.
Ohkubo K, Gotoh M. (2003) Effect of ramatroban, a thromboxane A2 antagonist, in the treatment of perennial allergic rhinitis. Allergology International 52: 131-138.
Gotoh M, Okubo K, Okuda M. (2003) Repeated antigen challenge in patients with perennial allergic rhinitis to house dust mite. Allergol Int 52: 207-212.
Okubo K, Pawankar R, Gotoh M, Yagi T. (1999) Adhesive explant culture of allergic nasal mucosa: Effect of emedastine difumarate, an anti-allergic drug. Jpn J Pharmacol 79: 351-356.
Okubo K, Okuda M. (1998) Time-course changes in nasal airway resistance after house dust antigen challenge: With special reference to late phase response. Allergol Int 47: 225-232.
Ohkubo K, Baraniuk JN, Hohman R, Merida M, Hersh LB, Kaliner MA. (1998) Aminopeptidase activity in human nasal mucosa. J. Allergy Clin. Immunol .102: 741-750.
Ohkubo K, Ikeda M, Pawankar R, Gotoh M, Yagi T, Okuda M. (1998) Mechanisms of IL-6, IL-8, and GM-CSF release in nasal secretions of allergic patients after nasal challenge. Rhinology 36; 156-161.
Nakamizo M, Pawankar R, Ohkubo K. (1998) Presence of endothelin-1 inhuman salivary glands and tumors. J Nippon Med Sch 65; 471-477.
Moss RB, Nagata H, Goff J, Okubo K, Hausfeld J, Kaliner MA. (1997) Constitutive mRNA and immunoreactivity for IL-2 in human nasal mucosa. Clin Exp Allergy 27: 406-412.
Baraniuk JN, Ohkubo K, Kwon OJ, Mak J, Davies R, Twort C, Kaliner MA, Letarte M Barnes PJ (1995) Localization of neutral endopeptidase (NEP) in human bronchi. Eur Respir J 8: 1458-1464.
Yokoshima K, Ohnishi M, Takizawa R, Okubo K, Yagi T, Okuda M. (1995) Distribution of mast cells in inverted papilloma and squamous cell carcinoma of the nose. Am J Rhinol 9: 57-62.
Pawankar RU, Okuda M, Hasegawa S, Suzuki K, Yssel H, Okubo K, Okumura K, Ra C. (1995) Interleukin-13 expression in the nasal mucosa of perennial allergic rhinitis. Am J Respir Crit Care Med 152: 2059-2067.
Ohkubo K, Baraniuk JN, Merida M, Hausfeld H, Okada H, Kaliner MA. (1995) Human nasal mucosal carboxypepetidase: Activity, location, and release. J Allergy Clin Immunol 96: 924-931.
Ohkubo K. (1994) Cytokine in nasal surface and nasal secretion. Am J Rhinol (suppl) 8: 282-284.
Xiao SF, Okuda M, Ohnishi M, Ohkubo K (1994) Specific IgA and IgG antibodies to house dust mite dermatophagoides farinae in nasal secretion. Arerugi 43: 634-644.
Ohkubo K, Lee CH, Baraniuk JN, Merida M, Hausfeld JN, Kaliner MA. (1994) Angiotensin -converting enzyme in the human nasal mucosa. Am J Respir Cell Mol Biol 11: 173-180.
Ohkubo K, Okuda M, Kaliner MA. (1994) Immunological localization of neuropeptide-degrading enzymes in nasal mucosa. Rhinology 32: 130-133.
Mullol J, Chowdhury BA, White MV, Ohkubo K, Rieves RD, Baraniuk J, Hausfeld JN, Shelhamer JH, Kaliner MA. (1993) Endothelin in human nasal mucosa. Am J Respir Cell Mol Biol 8: 393-492.
Ohkubo K, Hohman R, Kaulbach H, Hausfeld J, Merida M, Kaliner MA. (1993) Human nasal mucosa neutral endopeptidase; location, quantification, and release. Am J Respir Cell Mol Biol 9: 557-567.
Otsuka H, Ohkubo K, Seki H, Ohnishi M, Fujikura T (1993) Mast cell quantitation in nasal polyp, sinus mucosa and nasal turbinate mucosa. J Laryngol Otol 107: 418-422.
Peden DB, Swirsz M, Ohkubo K, Hahn B, Emery B, Kaliner MA. (1993) Nasal secretion of the ozone scavenger uric acid. Am Rev Respir Dis 148: 455-461.
Okuda M, Yen C, Okubo K, Foonant S, Ikeda M, Pawankar R. (1991) Intraepithelial cell population in the allergic nasal mucosa. Am J Rhinol 5: 219-225.
Otsuka H, Mezawa A, Ohnishi M, Okubo K, Seki H, Okuda M. (1991) Changes in nasal methachromatic cells during allergen immunotherapy. Clin Exp Allergy 21: 115-119.
Okuda M, Otsuka H, Sakaguchi K, Onishi M, Okubo K (1989) Effect of anti-allergic treatment on nasal surface basophilic metachromatic cells in allergic rhinitis. Allergy Proc 10: 23-26.
Fujikura T, Ishida M, Sekine K, Aoki H, Okubo K (2012) Solitary fibrous tumor arinsing from superior nasal turbinate; a case report. J Nippon Med Sch 79(5):373-376.
Yokoshima K, Nakamizo M, Kokawa T, Inai S, Sakanushi A, Saito Y, Okubo K (2011) Three cases of carcinoma of the hypopharynx developing as metachronous second primary cancers after total laryngectomy with radiotherapy for carcinoma of the larynx. J Nippon Med Sch 78(4):261-266.
Fujikura T, Okubo K (2011) Nasal myoepithelioma removed through endonasal andoscopic surgery: A case report. J Nippon Med Sch 77(5): 273-276.
Okayama Y, Matsumoto H, Odajima H, Takahagi S, Hide M, Okubo K.: Role of omalizumab in various allergic doseases. Allergol Int. 2020 Apr;69(2):167-177. doi: 10.1016/j.alit.2020.01.004. Epub 2020 Feb 14.PMID: 32067933
Okubo K, Kurono Y, Ichimura K, Enomoto T, Okamoto Y, Kawauchi H, Suzaki H, Fujieda S, Masuyama K; Japanese Society of Allergology.: Japanese Guideline for Allergic Rhinitis 2020. Allergol Int. 2020 May 27:S1323-8930(20)30050-2. doi: 10.1016/j.alit.2020.04.001. Online ahead of print.PMID: 32473790
Mullol J, Izquierdo I, Okubo K, Canonica GW, Bousquet J, Valero A.: Clinically relevant effect of rupatadine 20 mg and 10 mg in seasonal allergic rhinitis: a pooled responder analysis, Clin Transl Allergy. 2019 Oct 9;9:50. doi: 10.1186/s13601-019-0293-4. eCollection 2019.PMID: 31624533
Okubo K, Kurono Y, Ichimura K, Enomoto T, Okamoto Y, Kawauchi H, Suzaki H, Fujieda S, Masuyama K; Japanese Society of Allergology.: Japanese Guideline for Allergic Rhinitis 2014. Allergology Int. 2017 Apr;66(2):205-219. doi: 10.1016/j.alit.2016.11.001. Epub 2017 Feb 15. Review.
Okubo K, Kurono Y, Fujieda S, Ogino S, Uchio E, Odajima H, Takenaka H(2014) Japanese Society of Allergology: Japanese Guideline for Allergic Rhinitis 2014. Allergology Int 63: 357-375.
Ohta N, Ishida A, Kurakami K, Suzuki Y, Kakehata S, Ono J, Ikeda H, Okubo K, Izuhara K (2014) Expression and roles of periostine in otolarngological disease. Allergology Int 63(2): 171-180.
Yonekura S, Okamoto Y, Horiguchi S, Okubo K, Gotoh M, Konno A, Okuda M (2012) Early intervention for Jpapanese cedar and cypress pollinosis. Clin Exp Allergy Rev 12: 10-16.
Yuta A, Ogihara H, Yamanaka K, Ogawa Y, Mizutani H, Okubo K (2012) Therapeutic outcomes and immunological effect of sublingual immunotherapy for Jpapanese cedar pollinosis. Clin Exp Allergy Rev 12: 29-35.
Gotoh M, Okubo K (2012) Sublingual immunotherapy for Japanese cedar pollinosis: current status in Japan. Clin Exp Allergy Rev 12: 36-40.
Fujieda S, Kurono Y, Okubo K, Ichimura K, Enomoto T, Kawauchi H, Masuyama K, Goto M, Suzaki H, Okamoto Y, Takenaka Y (2012) Examination, diagnosis and classification for Japanese allergic rhinitis: Japanese guideline. Auris Nasus Larynx 39: 553-556.
Okubo K, Kurono Y, Fujieda S, Ogino S, Uchio E, Odajima H, Takenaka H, Baba K (2011) Japanese guideline for allergic rhinitis. Allergol Int 60: 171-189.
Okubo K, Gotoh M: Allergen immunotherapy for allergic rhinitis. (2010) J Nippon Med Sch 77(6): 285-289.
Okubo K, Gotoh M. (2009) Sublingual immunotherapy for Japanese cedar pollinosis. Allergol Int 58: 149-154.
Okubo K, Nagakura T. (2008) Anti-IgE antibody therapy for Japanese cedar pollinosis. Allergol Int 57: 205-209.
Hashiguchi K, Tang H, Fujita T, Suematsu K, Tsubaki S, Nagakura H, Kitajima S, Gotoh M, Okubo K. (2008) Pilot study of Japanese cedar pollen exposure using a nobel artificial exposure chamber (OHIO chamber). Clin Exp Allergy Rev 8: 30-36.
Naclerio R, Rosenwasser L, Ohkubo K. (2002) Allergic rhinitis: current and future treatments. Clin Exp Allergy Rev 2: 137- 147.
Pawankar R、奥田稔、大西正樹、大久保公裕（1993）ヒト鼻粘膜リンパ球の分布と粘膜免疫における意義．アレルギー－今日の考え方(Current Insights in Allergy) －9 No3．宮本昭正編集．スタンダードマッキンタイヤ（東京）11-14.
Okuda M, Otsuka H, Kawabori S, Ohnishi M, Sakaguchi K, Ohkubo K, Pawankar R, Seki H, Yokoshima K, Ra C (1998) Nasal mast cell heterogeneity. The Nose. P. van Cauwenberge, D.-Y. Wang, K.Ingel, C.Bachert, eds. Kugler publications (The Hauge/New York). 21-25.
Okuda M, Ohkubo K, Miura I. (1998) Mast cell stabilizers for the treatment of allergic rhinitis. The Nose. P. van Cauwenberge, D.-Y. Wang, K.Ingel, C.Bachert, eds. Kugler publications (The Hauge/New York). 285-289.
Okuda M, Yen C, Okubo K, Foonant S, Pawankar R (1992) Cellular elements in the nasal epithelium, especially nasal intraepithelial lymphocytes. In : Immunobiology in Otology, Rhinology, and Laryngology. McCabe BF, Veldman JE, Mogi G, eds. Kugler publications (The Hauge/New York). 185-193.
Okubo K: Treatment strategy for pollinosis in Japan. 第13回大韓耳鼻咽喉科医師会学術大会（ソウル）1
Okubo K: Unmet needs for the treatment of allergic rhinitis. The 7thresearch symposium on human nasal natural defense system. (Jeju, Korea) 2011.10
Okubo K: The future is with sublingual immunotherapy. Session4 in International Symposium on Immunotherapy. World Allergy Congress 2007. (Bangkok, Thai) December 2007.
Okubo K: Treatment of dacryocystitis due to nasolacriminal duct obstruction. 16thinternational course on endoscopic surgery of the nose and paranasal sinuses. (Korea, Seoul) April 2007.
Okubo K: The mechanism and the effect of sublingual immunotherapy for Japanese cedar pollinosis Asian Research Symposium in Rhinology (15th) Singapore 2012.5
Okubo K: Rash immunotherapy for allergic rhinitis. Round Table 10. XIV IRS and XXX ISIAN Tokyo2011. 9.22
Okubo K, Gotoh M: Japanese cedar pollinosis and circumstances. Harmony with climate and pollinosis”.Organizer: Norio Sahashi, J. Emberlin. 18th International Society of Biometeorology (Tokyo, Japan). September 2008.
Okubo K, Gotoh M, Okamoto Y: The clinical role and efficacy of pranlukast on allergic rhinitis. Symposium; The role of luekotorien receptor antagonist on bronchial asthma and allergic rhinitis. World Allergy Congress 2007. (Bangkok, Thai) December 2007.
Okubo K: The effect of new generation anti-histamine for pollinosis patients –artificial exposure chamber- Symposium; new insights of anti-histamines. World Allergy Congress 2007. (Bangkok, Thai) December 2007.
Gotoh M, Okubo K: Sublingual immunotherapy and nasal immunotherapy. 22ndInernational Symposium of Infection and Allergy of Nose (Symposium09: Allergic rhinitis: New therapeutic trial in nasal allergy) (Seoul, Korea) October 2003.
Okubo K: Anti- IgE therapy. 22ndInernational Symposium of Infection and Allergy of Nose (Symposium09: Allergic rhinitis: New therapeutic trial in nasal allergy) (Seoul, Korea) October 2003.
Okubo K, Okuda M: The development of quality of life questionnaire for allergic rhinitis in Japan. 8thAsian Research Symposium in Rhinology (Taipei, Tainan)(Satellite Symposium; Synergy on Management of Allergic Rhinitis) March 2003.
Nakamura S, et al. (3rd out of 10): Effect of immunotherapeutic peptide with T-cell epitopes to Japanese cedar allergen in monkey Cj pollinosis model. 17thInternational Congress of Allergology and Clinical Immunology (Sydney, Australia) October 2000.
Okubo K: Cytokine in nasal surface and nasal secretions. 10thInternational Sym. Infection and Allergy of Nose (Seoul, Korea) (Sym. 60: Cytokines in nasal allergy) October 1993.
Okubo K, Gotoh M: Protective efficacy of pranlukast hydrate for Japanese cedar pollinosis. 14thCongress of Asian Pacific Society of Rspirology (Seoul, Korea) November 2009.
Okubo K, et al. (1stout of 6): A double-blind cross-over controlled study of Pranlukast, a leukotriene receptor antagonist, against Japanese cedar pollinosis using the OHIO chamber. 7th symposium on experimental rhinology and immunology of the nose. (Dubrovnik, Croatia). November 2008.
Okubo K, Gotoh M, Okamoto Y: Double blind comparative study of pranlukast hydrate as initial treatment of cedar pollinosis. 12thJapan-Korea Joint meeting of otolaryngology-head and neck surgery. (Nara, Japan) March 2008.
Tang H, et al. (4 out of 7): Development of an artificial exposure chamber system using Japanese cedar pollen. XXV Congress of the European Academy of Allergology and Clinical Immunology (Vienna, Austria). June 2006.
Hashiguchi K, et al. (8 out of 8): Preliminary study on Japanese cedar pollinosis in an artificial exposure chamber (OHIO chamber). XXV Congress of the European Academy of Allergology and Clinical Immunology. (Vienna, Austria). June 2006.
Okubo K, Gotoh M, Okuda M: Epinastine hydrochloride protects the nasal reactivity by provocation tests with Japanese cedar pollen allergen better than placebo and fexofenadine hydrochloride. 19thWorld Allergy Congress. (Munch, Germany). June, 2005.
Okubo K, Imai T, Suzaki H: The efficacy of ramatroban in Japanese cedar pollinosis. Japan-Taiwan Conference in Otolaryngology Head and Neck Surgery (Tokyo, Japan) October 2003.
Okubo K, et al. (1stout of 6): Effect of fexofenadine HCl on quality of life and work productivity in Japanese patients with cedar pollinosis. World Allergy Organization Congress- XVIII ICACI (Vancouver, Canada) September 2003.
Okubo K, Ogino S, Nagakura T, Ishikawa T: Clinical efficacy and safety of omalizmab on seasonal allergic rhinitis induced by Japanese cedar pollen in the second pollen season. World Allergy Organization Congress- XVIII ICACI (Vancouver, Canada) September 2003.
Okubo K, Ogino S, Nagakura T, Ishikawa T: Clinical efficacy of Omalizmab on seasonal allergic rhinitis associated with Japanese cedar pollen. 60th Am. Acad. Allergy Athma & Immunol. (Denver, USA) March 2003.
Okubo K, Gotoh M, Okuda M: The effect of substance P on eosinophil function in allergic nasal mucosa. 6thInternational Academic Conference on Immuno-& Molecular Biology in otolaryngology (Jeju Island, Korea) October 2002.
Nakagawa T, et al. (6thout of 8): Evaluation of MAST-26, newly developed system for detection of IgE antibodies.. 17th International Congress of Allergology and Clinical Immunology (Sydney, Australia) October 2000.
Ohkubo K, Pawankar R, Okuda M: Prepro-endothelin and endothelin receptor expression in nasal surface after allergen challenge. 56th Am. Acad. Allergy Athma & Immunol. (San Diego, USA) March 2000.
Okuda M, Ohkubo K, Goto M: Intranasal pollen count for japanese cedar pollinosis.. 56th Am. Acad. Allergy Athma & Immunol. (San Diego, USA) March 2000.
Ohkubo K, Gotoh M, Okuda M: Adhesive explant culture of allergic nasal mucosa. 8th Japan-Korea Joint Allergy Symposium (Utsunomiya, Japan) November 1999.
Okubo,K., Okuda M: Late phase response of allergic rhinitis. Inter Congress Allergy and Clin Immunol (Cancun, Mexico) October 1997.
Ohkubo K, Gotoh M, Yagi T, Okuda M: Nasal provocation with bradykinin (BK) in normal and allergic subjects -effect of ACE inhibitor. 2nd Symposium of Experimental Rhinology and Immunology of the Nose (Rotterdam, Netherland) February 1996.
Okubo K, Pawankar R, Okuda M: Endothelin expression in the nasal epithelium of patients with allergic rhinitis, sinusitis and normals. 51th Am. Acad. Allergy Immunol. (NY, USA) March 1995.
Yokoshima K, et al. (5thout of 7) et al: Distribution of GM-CSF, IL-6 and IL-8 in nasal inverted papilloma of the nose and paranasal sinuses. 50th Am. Acad. Allergy & Immunol. (Anaheim, USA) March 1994.
Ohkubo K, et al. (1stout of 7): Endothelin production in human nasal epithelia l cell culture media, 50th Am. Acad. Allergy Immunol. (Anaheim, USA) March 1994.
Pawankar R, et al (3rdout of 6): Functional characteristic of the human nasal intraepithelial lymphocytes. 50th Am. Acad. Allergy Immunol. (Anaheim, USA) Mach 1994.
Yokoshima K, Ohnishi M, Ohkubo K, Okuda M, Yagi T: Distribution of mast cells and eosinophils in inverted papilloma and squamous carcinoma of the nose and paranasal sinuses. 10th International Sym. Infection and Allergy of Nose (Seoul, Korea) October 1993.
Ohkubo K: Preventive effect of Allergy Control Solution, an acaricide, on house dust mite. The 4th Japan-Korea Joint Meeting of Otolaryngology, Head and Neck Sur. (Kagoshima, Japan) November 1992.
Ohkubo K, Okuda M, Kaliner MA: Immunological localization of neuropeptide degrading enzymes in nasal mucosa. 9th Inetrnational Sym. Infection and Allergy of Nose (Rome, Italy) October 1992.
Peden D, Mannix M, Ohkubo K, Kaliner MA: Nasal airway peroxydase activity is induced by cholinergic and histamine nasal mucosal challenge. Am. Lung Assoc. 1992 Annual Meeting Am. Thoracic Soc. (Miami, USA) May 1992.
Moss R, et al (2ndout of 7): Interleukin 2 immunoreactivity in nasal mucosa. 48th Am. Acad. Allergy Immunol. (Orlando, USA) March 1992.
Ohkubo K, et al (1stout of 7): Nasal mucosa angiotensin converting enzyme: location and release. 48th Am. Acad. Allergy Immunol. (Orlando, USA) March 1992.
Peden D, Swersz M, Ohkubo K, Harn B, Kaliner MA: Elucidation of source of cholinergically- induced nasal secretory uric acid. 48th Am. Acad. Allergy Immunol. (Orlando, USA) March 1992.
Mullol J, et al. (3rdout of 8): Neuropeptide and endothelin effects on human nasal grandular secretion in vitro. Euro. Neuro- peptide Club (Innsbruk. Austria) January 1992.
Ohkubo K, Merida M, Hersh MA, Kaliner MA: Enkephalin degrading aminopeptidase in human nasal mucosa and secretions. International Congress Allergology and Clinical Immunology (Kyoto, Japan) October 1991.
Ohkubo K, et al. (1stout of 6): Carboxypeptidase N in the human nasal mucosa and secretions. 1991 Annual Meeting Am. Thoracic Soc. Am. Lung Assoc. (Anaheim, USA) May 1991.
Ohkubo K, et al (1stout of 6): Neutral endopeptidase in human nasal mucosa and nasal secretions. 47th Annual Meeting Am. Acad. Allergy and Immunol. (San Francisco, USA) March 1991.
Mullol J, et al (3rdout of 8): Endothelin in human nasal mucosa. 47th Annual Meeting Am. Acad. Allergy and Immunol. (San Francisco, USA) March 1991.
Okuda M, et al. (3rdof 8): Intraepithelial migrating cells in perenial allergic rhinitis. 45th Annual Meeting Am Acad. Allergy and Immunol. (Washington DC, USA) March 1989.
Okubo K, et al (1stout of 7): Randomized placebo controlled trial of sublingual immunotherapy for Japanese cedar pollinosis. Symposium 7. Immunotherapy, update and future. 第18回日本アレルギー学会春季臨床大会（東京）5
